Lazio look to Capocannoniere Ciro Immobile and Joaquin Correa, while Juventus can recapture top spot with Paulo Dybala and Cristiano Ronaldo.
It kicks off at the Stadio Olimpico at 19.45 GMT.
This is a top of the table showdown between third and second, but as Inter were held to a goalless draw by Roma last night, a victory would make Juventus the new leaders.
It won’t be easy, because Simone Inzaghi’s men have won their last six Serie A games and have the runaway top scorer in the tournament, Ciro Immobile.
The striker, who for a brief moment played for Juventus, has 17 Serie A goals this season, already more than Cristiano Ronaldo (six), Dybala (four) and Gonzalo Higuain (four) put together.
He is again partnered by Tucu Correa rather than Felipe Caicedo, but Patric, Adam Marusic, Valon Berisha and Jordan Lukaku are out of action.
Sergej Milinkovic-Savic, Lucas Leiva and Luis Alberto pull the midfield strings.
Juventus have lost Sami Khedira for three months following knee surgery, joining Giorgio Chiellini, Douglas Costa and Aaron Ramsey on the treatment table.
Federico Bernardeschi is therefore the trequartista again behind Ronaldo and Dybala, sending Higuain to the bench.
This is Dybala’s 200th appearance for Juventus in all competition.
Juventus have a famously excellent record against Lazio, losing only one of their last 29 Serie A meetings, with 22 wins and six draws.
Since that 2-0 defeat in December 2003, the Bianconeri left the Olimpico with 11 victories and three stalemates.
The referee this evening is Michael Fabbri, with Massimiliano Irrati in the VAR booth.
Lazio: Strakosha; Luiz Felipe, Acerbi, Radu; Lazzari, Milinkovic-Savic, Leiva, Luis Alberto, Lulic; Correa, Immobile
Juventus: Szczesny; Cuadrado, Bonucci, De Ligt, Alex Sandro; Bentancur, Pjanic, Matuidi; Bernardeschi; Dybala, Ronaldo
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