Milan stand by Krzysztof Piatek and Giacomo Bonaventura, while Sinisa Mihajlovic looks to Rodrigo Palacio and Andreas Skov Olsen for Bologna.
It kicks off at the Stadio Dall’Ara at 19.45 GMT.
This is the first match with Mihajlovic on the bench since he underwent a bone marrow transplant in his battle with leukaemia, having been diagnosed in July.
Bologna are fresh from a surprise 2-1 win away to Napoli and are eager to get their first home win since October 27.
Gary Medel is suspended, with Mitchell Dijks and Roberto Soriano injured, but Andreas Skov-Olsen gets the nod rather than Riccardo Orsolini.
Blerim Dzemaili and Nicola Sansone also support veteran striker Palacio.
Milan grabbed their first win under coach Stefano Pioli last week, thanks to a late Theo Hernandez strike against Parma.
He sticks with the same starting XI, so Piatek and Bonaventura keep their places, despite competition from Rafael Leao.
Lucas Paqueta is back on the bench after an injury, but Mattia Caldara and Leo Duarte are still out of action.
Milan have lost only one of their last 19 Serie A matches against Bologna (13W, 5D), a 1-0 setback in January 2016. At the time, the coach on the Rossoneri bench was Mihajlovic.
Their last Serie A defeat at the Dall’Ara was in March 2002, followed by nine wins and four draws.
Bologna: Skorupski; Tomiyasu, Bani, Danilo, Denswil; Dzemaili, Schouten, Poli; Skov-Olsen, Palacio, Sansone
Milan: G Donnarumma; Conti, Musacchio, Romagnoli, Theo Hernandez; Kessie, Bennacer, Calhanoglu; Suso, Piatek, Bonaventura
Watch Serie A live in the UK on Premier Sports for just £9.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://www.premiersports.com/subscribenow