Sampdoria surprisingly drop Manolo Gabbiadini for a Derby della Lanterna that is also a relegation six-pointer, while Genoa are forced into changes.
It kicks off at 19.45 GMT, follow the build-up and action as it happens from this game and Napoli-Parma on the LIVEBLOG.
Both these clubs have had a dismal season so far, sitting in the drop zone and with new coaches, having fired Aurelio Andreazzoli and Eusebio Di Francesco in October.
Thiago Motta played for Claudio Ranieri for just 13 games over six months at Inter, before moving to Paris Saint-Germain.
Goran Pandev and Kevin Agudelo are suspended, Andrea Favilli, Cristian Zapata, Lukas Lerager and Christian Kouame injured.
Stefano Sturaro is therefore used as a support for lone striker Andrea Pinamonti, due to the sheer shortage of options.
Marko Pajac is not 100 per cent fit, but still starts on the wing.
Sampdoria have to do without Jakub Jankto, Bartosz Bereszynski, Edgar Barreto, Andrea Bertolacci and Federico Bonazzoli.
Surprisingly, Ranieri has left Gabbiadini on the bench, instead using Gaston Ramirez in a more advanced role as support for Fabio Quagliarella.
Morten Thorsby is a midfielder, but has been playing as a defender for most of the season.
Genoa: Radu; Biraschi, Romero, Criscito; Ghiglione, Schone, Radovanovic, Cassata, Pajac; Sturaro; Pinamonti
Genoa bench: Marchetti, Jandrei, Goldaniga, Sanabria, El Yamiq, Jagiello, Favilli, Ankersen, Cleonise, Rovella
Sampdoria: Audero; Depaoli, Ferrari, Colley, Murru; Ekdal, Vieira, Thorsby, Linetty; Ramirez; Quagliarella
Sampdoria bench: Seculin, Falcone, Augello, Chabot, Rigoni, Caprari, Regini, Maroni, Murillo, Gabbiadini, Leris
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