Genoa make their debut under third coach of the season Davide Nicola, who starts Mattia Perin and Goran Pandev, while Sassuolo can’t rely on Domenico Berardi.
It kicks off at 17.00 GMT, follow all the action as it happens from today’s four Serie A games on the LIVEBLOG.
The Grifone have had a disastrous campaign so far, sitting bottom of the table and having already dismissed both Aurelio Andreazzoli and Thiago Motta.
Nicola was brought in over the Christmas break and hopes to turn another dire situation around after rescuing Crotone and Udinese from relegation.
President Enrico Preziosi has been busy revamping the squad too, with Perin arriving on loan from Juventus, Mattia Destro from Bologna and Valon Behrami as a free agent.
Perin is thrown straight into the starting XI, while Pandev returns from suspension to partner Antonio Sanabria upfront in a 3-5-2 formation.
Andrea Pinamonti is dropped to the bench along with Lasse Schone, though Christian Kouame, Riccardo Saponara and Lukas Lerager are injured.
Sassuolo have quite a few problems for coach Roberto De Zerbi to deal with, as talisman Domenico Berardi is still not fully fit.
He has also lost Marlon, Rogerio, Gregoire Defrel and Vlad Chiriches, while Manuel Locatelli is able to play despite flu symptoms.
Andrea Consigli returns in goal, having been out of action since the end of November.
Genoa: Perin; Biraschi, Romero, Criscito; Ankersen, Jagiello, Radovanovic, Sturaro, Pajac; Pandev, Sanabria
Sassuolo: Consigli; Toljan, Ferrari, Romagna, Kryiakopoulos; Obiang, Duncan, Locatelli; Traore, Caputo, Boga
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