Inter should have Stefano Sensi and Lautaro Martinez back in the starting XI, but Napoli are forced into changes by an injury crisis.
It kicks off at 19.45 GMT, click here for a match preview.
The Nerazzurri are joint Serie A leaders going into 2020, but have a tough test to begin the new decade, as they haven’t won a league game at the Stadio San Paolo since 1997.
Inter should have Stefano Sensi and Lautaro Martinez back in the starting XI, but Napoli are forced into changes by an injury crisis.
It kicks off at 19.45 GMT, click here for a match preview.
The Nerazzurri are joint Serie A leaders going into 2020, but have a tough test to begin the new decade, as they haven’t won a league game at the Stadio San Paolo since 1997.
Antonio Conte does receive good news from the Christmas break, as Stefano Sensi can make his first start since October 6, having finally recovered from a serious thigh strain.
Lautaro Martinez also returns from suspension to partner Romelu Lukaku, while even Alexis Sanchez is on the bench after three months out of action.
Danilo D’Ambrosio and Kwadwo Asamoah are on the treatment table, while Nicolò Barella is not quite ready to start yet.
Napoli won their first match under new coach Gennaro Gattuso, scraping a stoppage-time 2-1 comeback victory at Sassuolo to round off 2019.
It was still far from a convincing performance and they have more problems to deal with, as Kalidou Koulibaly, Dries Mertens, Nikola Maksimovic, Kevin Malcuit and Faouzi Ghoulam are all injured.
It remains to be seen whether Sebastiano Luperto will get the nod alongside Kostas Manolas, or bring in Giovanni Di Lorenzo to a makeshift centre-back role, the way he did in the second half against Sassuolo.
Fabian Ruiz is struggling with flu symptoms and poor form, so Eljif Elmas is ready to step in to midfield.
It looks as if Jose Callejon and Lorenzo Insigne will again flank Arkadiusz Milik in the 4-3-3 formation, leaving out record summer signing Hirving Lozano.
Probable line-ups
Napoli: Meret; Di Lorenzo, Manolas, Luperto, Mario Rui; Allan, Fabian Ruiz, Zielinski; Callejon, Milik, Insigne
Inter: Handanovic; Godin, De Vrij, Skriniar; Candreva, Gagliardini, Brozovic, Sensi, Biraghi, R Lukaku, Lautaro Martinez
Ref: Doveri