Zlatan Ibrahimovic leads the way with Rafael Leao in a relaunched 4-4-2 Milan side, while Cagliari try to end their negative run with Radja Nainggolan and Giovanni Simeone.
It kicks off at the Sardegna Arena at 14.00 GMT.
You can follow all the build-up and action as it happens from this game, Lazio-Napoli and Inter-Atalanta on the LIVEBLOG.
The Rossoneri are struggling to stay afloat in midtable after a 5-0 humiliation at the hands of Atalanta and their 0-0 draw with Sampdoria.
Ibrahimovic came off the bench for his ‘debut’ in a Milan jersey, but the 38-year-old is in the starting XI this time, sending Krzysztof Piatek, Suso and Jack Bonaventura to the touchline.
Ibra is partnered by Rafael Leao in a new 4-4-2 formation, as coach Stefano Pioli has got to shake things up, using Samu Castillejo and Hakan Calhanoglu as wingers.
Lucas Biglia, Ricardo Rodriguez and Leo Duarte are out of action.
Cagliari aren’t in much better shape either, as after a 13-round unbeaten run, they have now lost three in a row, including a 4-0 defeat at Juventus to start 2020.
Fabrizio Cacciatore, Luca Ceppitelli and Leonardo Pavoletti are still out injured, but Alessio Cragno is finally back on the bench after a lengthy lay-off.
Nahitan Nandez, Luca Cigarini and Marko Rog form the midfield, with Nainggolan supporting Joao Pedro and Cholito Simeone.
Milan have only lost one of their last 31 Serie A meetings with Cagliari, home and away. Aside from that 2-1 result in May 2017, they won 23 and drew seven.
Cagliari: Olsen; Faragò, Pisacane, Klavan, Pellegrini; Nandez, Cigarini, Rog; Nainggolan, Joao Pedro; Simeone
Cagliari bench: Rafael, Lykogiannis, Faragò, Walukiewicz, Birsa, Oliva, Ionita, Castro, Ladinetti, Cerri
Milan: G Donnarumma; Calabria, Musacchio, Romagnoli, Theo Hernandez; Castillejo, Kessie, Bennacer, Calhanoglu; Ibrahimovic, Leao
Milan bench: A Donnarumma, Reina, Conti, Gabbia, Krunic, Bonaventura, Paqueta, Brescianini, Piatek, Suso, Rebic
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