Juventus can be crowned Winter Champions with a victory and use Aaron Ramsey behind Paulo Dybala and Cristiano Ronaldo, while Roma look to Nicolò Zaniolo and Edin Dzeko.
It kicks off at the Stadio Olimpico at 19.45 GMT, you can follow all the build-up and action as it happens on the LIVEBLOG.
Inter were held 1-1 by Atalanta last night, a result that directly impacts where these two teams will stand at the midway stage of the season.
A win would make the Bianconeri sole Winter Champions, meaning they are top of the table halfway through the campaign, whereas Roma could go clear in fourth place.
The Giallorossi are fresh from a shock 2-0 home defeat to Torino and continue to miss Javier Pastore, Federico Fazio, Henrikh Mkhitaryan, Davide Santon, Justin Kluivert and Davide Zappacosta, while Leonardo Spinazzola is not fully fit.
There had been hints of a three-man defence with Mert Cetin, Gianluca Mancini and Chris Smalling, with tests in training, but coach Paulo Fonseca ultimately decided to stick with his usual 4-2-3-1 system.
Zaniolo, Diego Perotti and Lorenzo Pellegrini support Edin Dzeko upfront.
Rodrigo Bentancur continues his three-match ban, with Sami Khedira and Giorgio Chiellini injured, while Gonzalo Higuain is only fit for the bench.
Instead, Ramsey again takes the trequartista role behind Cristiano Ronaldo and Dybala.
Maurizio Sarri stands by Turkey international Merih Demiral for the fifth game in a row, leaving out massive signing Matthijs de Ligt.
It’s a return to the Stadio Olimpico for former Roma men Wojciech Szczesny and Miralem Pjanic.
Juventus already lost here 2-0 last season, but haven’t suffered two consecutive Serie A defeats to Roma since 1995.
These two coaches have met before, as Fonseca’s Shakhtar Donetsk knocked Sarri’s Napoli out of the Champions League.
Roma: Pau Lopez; Florenzi, Smalling, Mancini, Kolarov; Diawara, Veretout; Zaniolo, Pellegrini, Perotti; Dzeko
Roma bench: Fuzato, Mirante, Juan Jesus, Bruno Peres, Spinazzola, Cetin, Cristante, Under, Kalinic
Juventus: Szczesny; Cuadrado, Demiral, Bonucci, Alex Sandro; Rabiot, Pjanic, Matuidi; Ramsey; Dybala, Ronaldo
Juventus bench: Buffon, Pinsoglio, De Ligt, Rugani, De Sciglio, Danilo, Emre Can, Bernardeschi, Douglas Costa, Higuain, Pjaca
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