Juventus launch Douglas Costa alongside Gonzalo Higuain and Cristiano Ronaldo in the Coppa Italia quarter-final, as Roma are forced to reshuffle again.
It kicks off at the Allianz Juventus Stadium in Turin at 19.45 GMT.
The winner will be decided after 90 minutes or extra time and go on to face either Milan or Torino in the two-legged semi-final.
Maurizio Sarri brings in some different faces, such as Gianluigi Buffon in goal, Daniele Rugani in defence and Rodrigo Bentancur in midfield, while Paulo Dybala is initially rested in favour of Douglas Costa.
Initially, this’ll be part of a 4-3-3 formation, but the Brazilian has been tested as a trequartista behind the strikers too.
Alex Sandro and Juan Cuadrado are not 100 per cent fit, with Mattia De Sciglio, Giorgio Chiellini, Sami Khedira and Merih Demiral injured.
Roma have a decimated squad, because hitman Edin Dzeko sits out a ban, so Nikola Kalinic is the only real option upfront.
Javier Pastore, Federico Fazio, Nicolò Zaniolo, Diego Perotti, Henrikh Mkhitaryan, Mirco Antonucci and Davide Zappacosta are still injured.
It means squad rotation isn’t really possible just days before the Derby della Capitale with arch rivals Lazio in Serie A on Sunday.
Alessandro Florenzi and Aleksandar Kolarov do return, as they were suspended for the Serie A victory away to Genoa.
Juventus: Buffon; Danilo, Rugani, Bonucci, Alex Sandro; Bentancur, Pjanic, Rabiot; Douglas Costa, Higuain, Ronaldo
Juventus bench: Szczesny, Pinsoglio, De Ligt, Coccolo, Ramsey, Matuidi, Emre Can, Dybala, Cuadrado, Pjaca, Bernardeschi
Roma: Pau Lopez; Florenzi, Mancini, Smalling, Kolarov; Diawara, Cristante; Under, Pellegrini, Kluivert; Kalinic
Roma bench: Cardinali, Fuzato, Juan Jesus, Cetin, Santon, Fazio, Veretout, Peres, Spinazzola, Estrella
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