Milan welcome back Hakan Calhanoglu to support Zlatan Ibrahimovic and Rafael Leao, but Mario Balotelli is suspended, so Brescia look to Ernesto Torregrossa.
It kicks off at the Stadio Rigamonti at 19.45 GMT.
Football Italia Editor Susy Campanale takes you through the best Serie A bets of the week on Eurotips.
The Rossoneri have won all three games between Serie A and the Coppa Italia since moving to a 4-4-2 formation, a switch prompted by Zlatan Ibrahimovic’s arrival.
He is again partnered by Rafael Leao, with Calhanoglu returning from injury to take the left flank, Samu Castillejo preferred to Suso on the right.
January signing Simon Kjaer is chosen again rather than Mateo Musacchio, while Lucas Biglia, Davide Calabria and Leo Duarte are out injured.
Lucas Paqueta did not make the trip, reportedly because the Brazilian asked not to be included, as he is pushing for a transfer to PSG.
Brescia are without suspended star striker and former Milan forward Mario Balotelli, who received a two-match ban for insulting the referee during the 2-2 draw with Cagliari.
It means Ernesto Torregrossa and Florian Aye are the front pairing, with Romulo preferred to Simon Skrabb in the trequartista role and Sandro Tonali pulling the midfield strings.
Alfredo Donnarumma is only on the bench to begin with.
Daniele Dessena made his comeback last week as a substitute, having broken his leg on October 21.
Goalkeeper Jesse Joronen is able to start, despite suffering from flu symptoms over the last couple of days.
Brescia have only won one of their last 19 Serie A meetings with Milan, in May 2003, drawing nine and losing nine.
Brescia: Joronen; Sabelli, Cistana, Chancellor, Mateju; Bisoli, Tonali, Dessena; Romulo; Torregrossa, Aye
Brescia bench: Andrenacci, Alfonso, Gastaldello, Ndoj, Spalek, A Donnarumma, Mangraviti, Magnani, Skrabb, Viviani, Martella, Bjarnason
Milan: G Donnarumma; Conti, Kjaer, Romagnoli, Theo Hernandez; Castillejo, Kessie, Bennacer, Calhanoglu; Leao, Ibrahimovic
Milan bench: Begovic, A Donnarumma, Bonaventura, Suso, Piatek, Rebic, Musacchio, Krunic, Gabbia, Ricardo Rodriguez
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