Fiorentina use Federico Chiesa and Patrick Cutrone upfront, resting Dusan Vlahovic against bottom of the table Genoa.
It kicks off at the Stadio Franchi at 17.00 GMT.
You can follow the build-up and action as it happens from all today’s Serie A games on the LIVEBLOG.
The Viola have truly found their feet under new coach Beppe Iachini, winning three in a row between Serie A and the Coppa Italia, beating SPAL, Atalanta and Napoli.
Dalbert is suspended and replaced on the left of a five-man midfield by Lorenzo Venuti, with Pol Lirola still on the right.
Iachini had hinted he would unleash the all-new trident attack of Cutrone, Chiesa and Vlahovic, but is keeping the young Serbian on the bench to begin with.
Genoa dropped to the foot of the table when SPAL surprisingly beat Atalanta, so the pressure is growing on their third coach of the campaign Davide Nicola.
Domenico Criscito returns from suspension, but Francesco Cassata replaces him on the naughty step.
Christian Kouame, Lukas Lerager and Cristian Zapata are still injured, with Andrea Pinamonti and Jandrei awaiting transfers.
Andrea Favilli gets the nod alongside Goran Pandev this time, rather than Antonio Sanabria.
Fiorentina: Dragowski; Milenkovic, Pezzella, Caceres; Lirola, Benassi, Pulgar, Castrovilli, Venuti; Chiesa, Cutrone
Genoa: Perin; Biraschi, Romero, Criscito; Ghiglione, Behrami, Schone, Sturaro, Barreca; Pandev, Favilli
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