Roma have new signings Carles Perez and Gonzalo Villar on the bench, but rely on Lorenzo Pellegrini against Domenico Berardi and Jeremie Boga’s Sassuolo.
It kicks off at the Mapei Stadium at 19.45 GMT.
The Giallorossi are still decimated by injuries and their new January signings have only just arrived, so Carles Perez and Gonzalo Villar are on the bench.
Alessandro Florenzi was loaned to Valencia, with Amadou Diawara, Nicolò Zaniolo, Henrikh Mkhitaryan and Davide Zappacosta injured.
Davide Santon and Leonardo Spinazzola are again the full-backs, with Cengiz Under, Justin Kluivert and ex-Sassuolo star Lorenzo Pellegrini supporting Edin Dzeko.
Sassuolo have to do without suspended Federico Peluso, who saw red in their 0-0 draw at Sampdoria last week, a result earned despite being down to 10 men for an hour.
Vlad Chiriches is on the treatment table, with Gregoire Defrel not fully fit either.
Berardi and Boga are joined by Filip Djuricic rather than Hamed Junior Traore behind Francesco Caputo.
Gian Giacomo Magnani was brought back from his loan spell at Brescia on transfer deadline day, but Alfred Duncan sold to Fiorentina.
Sassuolo have just two wins in their last 10 Serie A games and have never beaten Roma in the top flight, managing only five draws from 13 meetings.
Sassuolo: Consigli; Toljan, Ferrari, Romagna, Kyriakopoulos; Obiang, Locatelli; Berardi, Djuricic, Boga; Caputo
Sassuolo bench: Pegolo, Turati, Marlon, Magnanelli, Rogerio, Defrel, Muldur, Raspadori, Traore, Magnani, Piccinini, Bourabia
Roma: Pau Lopez; Santon, Mancini, Smalling, Spinazzola; Veretout, Cristante; Under, Pellegrini, Kluivert; Dzeko
Roma bench: Fuzato, Mirante, Perotti, Kolarov, Villar, Cetin, Kalinic, Fazio, Pastore, Perez, Bruno Peres, Ibanez,
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