Roma draft in Henrikh Mkhitaryan and Diego Perotti to replace suspended Lorenzo Pellegrini, while Bologna look to Rodrigo Palacio and Musa Barrow.
It kicks off at 19.45 GMT, you can follow the build-up and action as it happens on the LIVEBLOG.
The Giallorossi are stuttering lately and were caught in fourth place by Atalanta after losing three of their last five Serie A games.
The injury crisis is taking its toll, missing Amadou Diawara, Nicolò Zaniolo, Davide Zappacosta and this evening also suspended Pellegrini.
Javier Pastore and Henrikh Mkhitaryan are not 100 per cent fit either after long lay-offs, but Mkhitaryan still gets the nod with Perotti.
They join Cengiz Under to support Edin Dzeko, leaving off-form Justin Kluivert on the touchline.
Aleksandar Kolarov returns to the left-back role, sending Leonardo Spinazzola to the bench, but Davide Santon remains on the right.
Bologna make the trip without banned midfielder Andrea Poli, while Gary Medel, Federico Santander, Nicola Sansone, Ladislav Krejci and Mitchell Dijks are injured.
It means January signing from Atalanta Musa Barrow gets his first start in the Rossoblu jersey, with Riccardo Orsolini and Rodrigo Palacio in a trident attack.
Coach Sinisa Mihajlovic spent the last couple of weeks undergoing anti-viral treatment as part of his leukaemia battle, but was allowed out for their 2-1 win over Brescia.
He was formally released from the clinic this morning and immediately travelled down to Rome so he could attend the match.
Roma: Pau Lopez; Santon, Mancini, Smalling, Kolarov; Veretout, Cristante; Under, Mkhitaryan, Perotti; Dzeko
Bologna: Skorupski; Tomiyasu, Danilo, Bani, Denswil; Svanberg, Schouten, Soriano; Orsolini, Palacio, Barrow
Watch Serie A live in the UK on Premier Sports for just £11.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://subscribe.premiersports.tv/