Napoli seek a fourth straight win in all competition and ring the changes against Lecce, as Kalidou Koulibaly returns and Matteo Politano gets his full debut.
It kicks off at the Stadio San Paolo at 14.00 GMT.
You can follow the build-up and action as it happens from all today’s Serie A games on the LIVEBLOG.
Napoli seek a fourth straight win in all competition and ring the changes against Lecce, as Kalidou Koulibaly returns and Matteo Politano gets his full debut.
It kicks off at the Stadio San Paolo at 14.00 GMT.
You can follow the build-up and action as it happens from all today’s Serie A games on the LIVEBLOG.
Gennaro Gattuso has got the Partenopei right back on track with three victories in a row between Serie A and the Coppa Italia.
The injury list is also starting to empty out, with the January signings beginning to make an impact too, giving the coach plenty of alternatives.
Today’s big news is the return of Koulibaly for the first time since suffering a hamstring strain seven weeks ago, and he is thrown straight into the starting XI.
Kostas Manolas is rested, having flown to Greece over the last few days to meet his new-born daughter, so Nikola Maksimovic is also back from his injury lay-off, moving Giovanni Di Lorenzo to his natural role of right-back.
Eljif Elmas is suspended, with Faouzi Ghoulam, Kevin Malcuit and transfer-listed Amin Younes unavailable.
Politano made the transfer from Inter in January and he gets his first start in the trident attack with Arkadiusz Milik and Lorenzo Insigne.
Diego Demme is fast becoming a first choice midfielder, especially with Fabian Ruiz not fully fit, and Stanislav Lobotka is preferred to Allan.
Lecce are fresh from a morale-boosting 4-0 demolition of Torino, a result that cost coach Walter Mazzarri – formerly of Napoli – his job.
Fabio Liverani also celebrated the Panchina d’Argento award this week, voted the best Serie B coach of the 2018-19 campaign.
Diego Farias, Khouma Babacar and goalkeeper Gabriel are out of action, so Mauro Vigorito again goes in goal.
Mid-season signing Antonin Barak scored on his debut and starts again, while Riccardo Saponara passes a late fitness test to start behind Gianluca Lapadula and Filippo Falco.
Lecce have only ever won one of their 10 Serie A trips to the San Paolo, 4-2 in March 1998, along with two draws and seven losses.
Napoli: Ospina; Di Lorenzo, Maksimovic, Koulibaly, Mario Rui; Lobotka, Demme, Zielinski; Politano, Milik, Insigne
Lecce: Vigorito; Rispoli, Lucioni, Rossettini, Donati; Majer, Deiola, Barak; Saponara; Lapadula, Falco
Ref: Giua