Lazio can close to within a point of leaders Juventus, but have several key players missing for this tricky trip to Parma.
It kicks off at the Stadio Tardini at 17.00 GMT.
The Biancocelesti have a massive opportunity to not only set a new all-time club record by going 18 rounds unbeaten, but also close to within one point of leaders Juventus.
That’s because last night the Bianconeri lost 2-1 at Hellas Verona, the same team that Lazio drew 0-0 with in Wednesday’s rescheduled Week 17 fixture.
However, Simone Inzaghi has to do without suspended Sergej Milinkovic-Savic and Stefan Radu, while Senad Lulic is injured.
Joaquin Correa returns, although he is not 100 per cent fit, so Felipe Caicedo again supports Capocannoniere Ciro Immobile.
There’s another reason for Lazio to be anxious, as next week is the showdown for second place with Inter.
They have four players who are a yellow card away from suspension: Immobile, Francesco Acerbi, Luiz Felipe and Danilo Cataldi.
As for Parma, their injury crisis drags on, with Roberto Inglese, Matteo Scozzarella and Luigi Sepe out of action.
Yann Karamoh, Andreas Cornelius and Dejan Kulusevski are all carrying injuries, but Cornelius is able to start.
Gervinho isn’t even in the squad, as he tried to push through a deadline day transfer to Al-Sadd and the paperwork wasn’t registered in time.
January signing Gianluca Caprari arrived from Sampdoria and he is chosen to form the unusual trident attack with Juraj Kucka and Cornelius.
Ionut Radu made his deadline day loan from Inter, via Genoa, but is again on the bench in favour of Colombi.
Parma have a famously poor record against Lazio, losing each of their last six Serie A meetings, conceding at least two goals every time.
Parma: Colombi; Darmian, Iacoponi, Bruno Alves, Gagliolo; Hernani, Brugman, Kurtic; Caprari, Cornelius, Kucka
Lazio: Strakosha; Patric, Luiz Felipe, Acerbi; Marusic, Parolo, Leiva, Luis Alberto, Jony; Caicedo, Immobile
Ref: Di Bello
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