Inter start Alexis Sanchez, Romelu Lukaku and Diego Godin, but not Christian Eriksen, while Milan change tactics with Hakan Calhanoglu and Ante Rebic supporting Zlatan Ibrahimovic.

It kicks off at 19.45 GMT at a packed out Stadio Giuseppe Meazza.

You can follow the build-up and action as it happens and give your views on the LIVEBLOG.

Inter start Alexis Sanchez, Romelu Lukaku and Diego Godin, but not Christian Eriksen, while Milan change tactics with Hakan Calhanoglu and Ante Rebic supporting Zlatan Ibrahimovic.

It kicks off at 19.45 GMT at a packed out Stadio Giuseppe Meazza.

You can follow the build-up and action as it happens and give your views on the LIVEBLOG.

This is a huge fixture and finds the two local rivals much closer in recent form than the 19-point gap in the standings would suggest.

Inter have the chance to catch leaders Juventus at the top of the table, but Lautaro Martinez and Alessandro Bastoni are suspended.

Antonio Conte kept everyone guessing with various options, including Christian Eriksen in a more advanced role in support of Romelu Lukaku, but has seemingly opted for a traditional 3-5-2 with Alexis Sanchez replacing Lautaro Martinez.

This allows Marcelo Brozovic, returning to the starting XI after injury, to take full control of the midfield, and sends new star signing Eriksen to the bench.

Samir Handanovic is not risked after a hairline fracture to the little finger in his left hand, despite suggestions he would try to play with a protective glove, as there is the very real risk of doing worse damage.

Godin is given the nod with Bastoni suspended, despite reports Danilo D’Ambrosio would be chosen instead as a makeshift centre-back.

Milan have Ibrahimovic and Simon Kjaer back after they missed the 1-1 draw with Hellas Verona, with both going straight into the starting XI.

Ismael Bennacer also returns following suspension, but Rade Krunic is out for a month with a stress fracture in his foot.

Coach Stefano Pioli takes a page from Conte’s tactical playbook and also uses a more creative figure right behind the centre-forward, in this case Calhanoglu.

It’s a disguised 4-4-1-1, though, because Samu Castillejo and Ante Rebic on the wings will spend much of their time pushing forward, creating a 4-2-3-1.

Milan have not beaten Inter in Serie A since a 3-0 ‘home’ result in January 2016, managing only three draws and four defeats, including three losses on the bounce.

Inter: Padelli; Godin, De Vrij, Skriniar; Candreva, Vecino, Brozovic, Barella, Young; Alexis Sanchez; R Lukaku 

Inter bench: Handanovic, Stankovic, Moses, Sensi, Ranocchia, Asamoah, Borja Valero, Eriksen, Esposito, Agoume, D’Ambrosio, Biraghi

Milan: G Donnarumma; Conti, Kjaer, Romagnoli, Theo Hernandez; Castillejo, Kessie, Bennacer, Rebic; Calhanoglu; Ibrahimovic

Milan bench: Begovic, A Donnarumma, Calabria, Gabbia, Laxalt, Musacchio, Biglia, Bonaventura, Brescianini, Paquetà, Saelemaekers, Leao

Ref: Maresca

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