Inter start Romelu Lukaku, Lautaro Martinez and Stefano Sensi against Napoli’s Dries Mertens, but Lorenzo Insigne and Kalidou Koulibaly are out of the Coppa Italia semi-final.
The first leg kicks off at 19.45 GMT at San Siro, with the second leg in Naples on March 5.
The Nerazzurri are coming off a comeback from 2-0 down to beat Milan 4-2 in the dramatic Derby della Madonnina, so confidence is sky high, whereas the Partenopei lost 3-2 at home to Lecce.
Lautaro Martinez is back in business, as he sat out a two-match Serie A ban, but that does not apply to the Coppa Italia.
He’s eager to get some playing time in his legs ahead of Sunday’s Scudetto showdown with Lazio, too.
Romelu Lukaku gets no rest, partnering the Argentine, with Alexis Sanchez and Sebastiano Esposito on the bench.
Samir Handanovic is still out with a fractured finger on his left hand, so Daniele Padelli starts his third consecutive match in goal.
Christian Eriksen is again initially left out, with Marcelo Brozovic taking the captain’s armband and Stefano Sensi returning from injury.
Ashley Young and Antonio Candreva are rested, with Alessandro Bastoni back from his Serie A ban to replace Diego Godin.
Napoli make the trip without injured Faouzi Ghoulam, Kevin Malcuit, suspended Elseid Hysaj and transfer-listed Amin Younes.
Kalidou Koulibaly did travel to Milan, but is suffering from muscular issues after his long lay-off, so is not risked in defence.
Lorenzo Insigne picked up a knock in training and is also left on the bench, so Eljif Elmas steps in with Piotr Zielinski and Diego Demme in midfield.
It remains to be seen if Elmas is part of the trident on the left, or if he’s in midfield for a 4-4-2, but it is yet another blow for Hirving Lozano, who has barely featured under Gennaro Gattuso.
This is also Mertens’ first start since Gattuso took over from Carlo Ancelotti in December, as he has been struggling with injury.
Matteo Politano is on the bench against the club he left in the January transfer window.
Inter are unbeaten in 10 competitive games, winning six, their longest run since 19 under Luciano Spalletti in December 2017.
Inter: Padelli; Skriniar, De Vrij, Bastoni; Moses, Barella, Brozovic, Sensi, Biraghi; Lautaro Martinez, R Lukaku
Inter bench: Handanovic, Stankovic, Berni, Godin, Alexis Sanchez, Vecino, Ranocchia, Young, Borja Valero, Eriksen, D’Ambrosio, Candreva
Napoli: Ospina; Di Lorenzo, Manolas, Maksimovic, Mario Rui; Fabian Ruiz, Demme, Zielinski; Callejon, Mertens, Elmas
Napoli bench: Meret, Karnezis, Koulibaly, Luperto, Allan, Lobotka, Insigne, Llorente, Lozano, Milik, Politano