Milan rely on Zlatan Ibrahimovic, Ante Rebic and Hakan Calhanoglu against Juventus with Cristiano Ronaldo, Paulo Dybala and Juan Cuadrado trident in the Coppa Italia semi-final.
The first leg kicks off at San Siro at 19.45 GMT, with the return in Turin on March 4.
Both these sides are in need of a boost after losing their Serie A matches at the weekend, as Milan fumbled a 2-0 lead in the derby with Inter, while Juve fell 2-1 at Hellas Verona.
Stefano Pioli makes just one change from the side that lost 4-2 to Inter, as Davide Calabria steps in for suspended Andrea Conti at right-back.
Otherwise, it’s the same 4-4-1-1 formation with Hakan Calhanoglu in a more creative role behind Ibrahimovic, sending Samu Castillejo and Ante Rebic out wide.
Juventus made the trip without Douglas Costa, Federico Bernardeschi, Sami Khedira, Giorgio Chiellini and Merih Demiral.
Former Milan flop Gonzalo Higuain is benched along with Adrien Rabiot and Rodrigo Bentancur, but the changes are not so much personnel as roles.
Juan Cuadrado goes from right-back to his traditional position on the right side of the trident attack with Dybala and Ronaldo, while Aaron Ramsey shifts back from trequartista to midfielder.
Leonardo Bonucci and Mattia De Sciglio are also facing their former club, while Gigi Buffon gets a rare start in goal just weeks after turning 42.
The Rossoneri have to be careful, as there are five players who are one yellow card away from suspension for the second leg. They are Ibrahimovic, Simon Kjaer, Samu Castillejo, Theo Hernandez and Ante Rebic.
Juve players on the verge of a Coppa Italia ban are Blaise Matuidi and Higuain.
It is sold out at the Stadio Giuseppe Meazza this evening with approximately 72,000 tickets sold, making it the biggest attendance in Coppa Italia semi-final history.
Milan: G Donnarumma; Calabria, Kjaer, Romagnoli, Theo Hernandez; Kessie, Bennacer; Castillejo, Calhanoglu, Rebic; Ibrahimovic
Milan bench: Begovic, A Donnarumma, Bonaventura, Leao, Musacchio, Paqueta, Gabbia, Saelemaekers, Laxalt, Brescianini, Maldini
Juventus: Buffon; De Sciglio, De Ligt, Bonucci, Alex Sandro; Ramsey, Pjanic, Matuidi; Cuadrado, Dybala, Ronaldo
Juventus bench: Szczesny, Pinsoglio, Danilo, Higuain, Rugani, Rabiot, Bentancur, Olivieri, Coccolo
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