Ciro Immobile, Felipe Caicedo and Sergej Milinkovic-Savic take on Romelu Lukaku, Lautaro Martinez and Marcelo Brozovic in the Lazio-Inter Scudetto showdown.
It kicks off at the Stadio Olimpico in Rome at 19.45 GMT.
Only one point separates these teams going into the weekend, as Inter were joint leaders with Juventus, feeling the Aquile breathing down their necks.
Juve beat Brescia 2-0 earlier this afternoon, so the race is on to keep up with Maurizio Sarri’s men.
Lazio are unbeaten in a club record 18 Serie A rounds, stretching back to a 1-0 defeat to Inter at San Siro in September.
Immobile is the Capocannoniere on 25 goals and he is again partnered by Felipe Caicedo, despite strong reports Joaquin Correa would play after injury.
Senad Lulic is out for a month after ankle surgery, so Jony takes the left wing-back role, with Adam Marusic on the right, Milinkovic-Savic, Luis Alberto and Lucas Leiva in midfield.
Inter are still missing goalkeeper and captain Samir Handanovic, who suffered a hairline fracture to his little finger, so Daniele Padelli is again in goal.
Stefano Sensi, Roberto Gagliardini, Kwadwo Asamoah and Sebastiano Esposito are out injured, but Matias Vecino gets the nod rather than January arrival Christian Eriksen in midfield.
Ashley Young and Antonio Candreva take the wings, with Diego Godin preferred to Alessandro Bastoni in the back three.
This evening is also a family reunion, as Romelu Lukaku’s brother Jordan is on the Lazio bench.
Lazio: Strakosha; Luiz Felipe, Acerbi, Radu; Marusic, Milinkovic-Savic, Leiva, Luis Alberto, Jony; Caicedo, Immobile
Lazio bench: Proto, Guerrieri, Patric, Bastos, Vavro, Lazzari, Cataldi, Parolo, J Lukaku, A Anderson, Correa, Adekanye
Inter: Padelli; Godin, De Vrij, Skriniar, De Vrij; Candreva, Barella, Brozovic, Vecino, Young; R Lukaku, Lautaro Martinez
Inter bench: Handanovic, Stankovic, Berni, Alexis Sanchez, Moses, Ranocchia, Borja Valero, Eriksen, Agoume, D’Ambrosio, Biraghi, Bastoni
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