Napoli will have to cope without Kalidou Koulibaly when Lionel Messi arrives at the San Paolo in their first leg against Barcelona in the Champions League.
The match starts at 20:00 GMT.
Gennaro Gattuso might deviate from his usual 4-3-3 formation and could be looking to limit Barcelona with a 4-1-4-1, where winter signing Diego Demme could play as a holding midfielder to help out the back four against Lionel Messi and Antoine Griezmann.
The whole city expects a great show at the San Paolo tonight and as Quique Setien arrives in Naples without Luis Suarez and Ousmane Dembele at his disposal, he also has to cope without Sergi Roberto and Jordi Alba.
But the home side will have to prepare to face the Blaugrana without their most important defender Koulibaly and will have to trust Kostas Manolas and Nikola Maksimovic in the heart of the defence.
Mario Rui should be at left-back, whilst Giovanni Di Lorenzo will keep his place at the right. David Ospina has been confirmed in goal and Fabian Ruiz will most likely be accompanied by another creative midfielder in Piotr Zielinski.
Arturo Vidal is expected to sit behind Messi and Griezmann to provide support and it could be busy night with a lot of duels between him and Demme.
Napoli (probable): Ospina; Di Lorenzo, Maksimovic, Manolas, Mario Rui; Demme; Callejon, Fabian Ruiz, Zielinski, Insigne; Mertens
Barcelona (probable): Ter Stegen; Semedo, Pique, Lenglet, Junior Firpo; Rakitic, Busquets, De Jong; Vidal; Griezmann, Messi
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