Atalanta start Ruslan Malinovskyi with Papu Gomez and Duvan Zapata, but Lazio have injury concerns and pick Joaquin Correa with Ciro Immobile in this top four showdown.
It kicks off at the Gewiss Stadium in Bergamo at 20.45 UK time (19.45 GMT).
This is the first game since February 29 for Lazio, who need a victory to stay within a point of leaders Juventus.
They were on such sparkling form before the lockdown that there’s the very real fear this has stalled their momentum, especially with injuries ruling out Senad Lulic, Lucas Leiva, Luiz Felipe, Adam Marusic and Bobby Adekanye.
Luis Alberto isn’t 100 per cent fit either, but he starts with Danilo Cataldi and Sergej Milinkovic-Savic, as Correa gets the nod ahead of Felipe Caicedo to support Capocannoniere Immobile.
Atalanta picked up exactly where they left off, as in the rescheduled Week 25 game with Sassuolo, they ran out 4-1 winners and there could comfortably have been more goals from both sides.
Josip Ilicic was out injured for that match with a slight ankle sprain and is now only fit for the bench.
Mario Pasalic is suspended, so Ruslan Malinovskyi steps in to the attacking trio.
Duvan Zapata bagged a brace at the weekend and is supported by Papu Gomez, but coach Gian Piero Gasperini is in the stands due to a touchline ban for dissent.
These are the great entertainers of Serie A, as Atalanta scored 74 goals and Lazio 60, more than any other club.
Neutrals can only hope for a repeat of the reverse fixture in Rome, when Atalanta took a commanding 3-0 lead only to be pegged back to 3-3 in stoppages.
The last seven league encounters between these teams provided a total 29 goals.
Atalanta are unbeaten in their last five Serie A meetings with Lazio, home and away, winning two and drawing three.
Atalanta: Gollini; Toloi, Palomino, Djimsiti; Hateboer, Freuler, De Roon, Gosens; Gomez; Malinovskyi, Duvan Zapata
Atalanta bench: Sportiello, Rossi, Bellanova, Czyborra, Caldara, Sutalo, Ilicic, Tameze, Colley, Castagne, Muriel
Lazio: Strakosha; Patric, Acerbi, Radu; Lazzari, Milinkovic-Savic, Cataldi, Luis Alberto, Jony; Correa, Immobile
Lazio bench: Proto, Guerrieri, Vavro, Jorge Silva, Bastos, Armini, Falbo, Parolo, Lukaku, A. Anderson, D. Anderson, Caicedo