Inter are forced to revamp with Diego Godin and Danilo D’Ambrosio in defence, taking on sparkling Parma forwards Andreas Cornelius and Dejan Kulusevski.
It kicks off at the Stadio Tardini at 20.45 UK time (19.45 GMT).
Antonio Conte must watch this one from the stands due to a touchline ban, accompanied by Milan Skriniar, who begins his three-game suspension.
Marcelo Brozovic, Stefano Sensi and Matias Vecino are injured, so Godin and D’Ambrosio get rare starts in defence, with Roberto Gagliardini and Nicolò Barella in midfield.
Cristiano Biraghi impressed as a substitute against Sassuolo and is here preferred to Ashley Young.
Christian Eriksen is in the trequartista role behind Romelu Lukaku and Lautaro Martinez.
Inter’s Scudetto hopes were practically wiped out after fumbling the lead for a 3-3 draw with Sassuolo midweek.
Parma, meanwhile, earned a 4-1 win away to Genoa thanks to the Cornelius hat-trick and the Dane again leads the way with Gervinho and future Juventus player Kulusevski.
Those results put the Ducali in the running for a place in the Europa League.
Simone Iacoponi is suspended, with Roberto Inglese injured, but Bruno Alves and Juraj Kucka shake off knocks to start.
Parma: Sepe; Laurini, Dermaku, Bruno Alves, Gagliolo; Kucka, Scozzarella, Kurtic; Kulusevski, Cornelius, Gervinho
Inter: Handanovic; D'Ambrosio, De Vrij, Godin; Candreva, Barella, Gagliardini, Biraghi; Eriksen; Lukaku, Lautaro Martinez
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