Felipe Caicedo, Marco Parolo and Luis Alberto shake off knocks to start with Ciro Immobile against a reshuffled Torino, who use Simone Verdi with Andrea Belotti.
It kicks off at the Stadio Olimpico Grande Torino at 18.30 UK time (17.30 GMT).
Simone Inzaghi is going to have to watch from the stands due to a touchline ban, as at least momentarily his men can close the gap from leaders Juventus back to one point.
Senad Lulic, Luiz Felipe, Lucas Leiva and Bobby Adekanye are still out of action, but Parolo, Luis Alberto and Caicedo have shaken off knocks to start.
Immobile is up against his former club, who he played for in two different eras.
Toro are struggling to stay out of the relegation zone and fresh from a 4-2 defeat away to Cagliari.
Daniele Baselli is out for the rest of the season, while Simone Zaza is only fit enough for a place on the bench.
Simone Verdi instead gets a rare start, the former Napoli flop still trying to find his position in the Toro side, who are increasingly reliant on Belotti.
It’s an intriguing battle of two first choice Italy centre-forwards and very good friends, Belotti and Immobile.
Torino: Sirigu; Lyanco, Nkolou, Bremer; De Silvestri, Lukic, Rincon, Meite, Aina; Belotti, Verdi
Lazio: Strakosha; Patric, Acerbi, Radu; Lazzari, Milinkovic-Savic, Parolo, Luis Alberto, Jony; Caicedo, Immobile
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