Juventus rely on Paulo Dybala, Cristiano Ronaldo and future Barcelona star Miralem Pjanic for what has historically been a tricky trip to relegation battlers Genoa.
It kicks off at the Stadio Luigi Ferraris, commonly known as Marassi, at 20.45 UK time (19.45 GMT).
The Bianconeri are eager to at least consolidate, if not extend, their four-point lead at the top of the Serie A table.
Giorgio Chiellini, Alex Sandro, Sami Khedira, Mattia De Sciglio and Merih Demiral are still out of action, with Gonzalo Higuain fit only for a substitute’s role.
That means Dybala and Ronaldo are again supported by Federico Bernardeschi, who might finally have found the role that suits him in the 4-3-3 formation.
Pjanic signed for Barcelona just 24 hours ago, but will see out the season with Juventus and starts in midfield.
Genoa are one point off the relegation zone, having fought back from 2-0 down to draw 2-2 with Brescia at the weekend and get themselves out of the bottom three.
Domenico Criscito and Ivan Radovanovic are injured, but there are several former Juve players in the squad, including Mattia Perin and Cristian Romero – who are on loan – Andrea Favilli and Stefano Sturaro.
Coach Davide Nicola rotates again, using Favilli and Federico Pinamonti upfront rather than Iago Falque or Antonio Sanabria.
Juve traditionally struggle at Marassi, losing three of their last six Serie A visits.
Genoa: Perin; Romero, Soumaoro, Masiello; Ghiglione, Behrami, Cassata, Schone, Sturaro; Favilli, Pinamonti
Genoa bench: Marchetti, Radaelli, Zapata, Barreca, Goldaniga, Lerager, Sanabria, Falque, Biraschi, Jagiello, Pandev, Destro
Juventus: Szczesny; Cuadrado, De Ligt, Bonucci, Danilo; Bentancur, Pjanic, Rabiot; Bernardeschi, Dybala, Ronaldo
Juventus bench: Buffon, Pinsoglio, Rugani, Wesley, Ramsey, Matuidi, Muratore, Douglas Costa, Higuain, Olivieri
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