Juventus are finding their groove with Paulo Dybala, Cristiano Ronaldo and Federico Bernardeschi, while Gigi Buffon makes history in the Derby della Mole against Andrea Belotti’s Torino.
It kicks off at 16.15 UK time (15.15 GMT) at the Allianz Juventus Stadium.
If you fancy a punt, then check out the betting preview for Juventus v Torino on Eurotips.co.uk.
Maurizio Sarri finally seems to have found the right combination for his Juventus team, as the 3-1 thrashing of Genoa saw one spectacular goal after another.
Bernardeschi continues to be preferred to Douglas Costa in the trident, with Dybala as a centre-forward and Cristiano Ronaldo in a wider role.
Alex Sandro, Giorgio Chiellini, Mattia De Sciglio, Sami Khedira and Merih Demiral are still out of action, so Juan Cuadrado and Danilo are again the full-backs.
Miralem Pjanic has already signed for Barcelona, but is still pulling the midfield strings in Turin.
It’s an historic occasion for Gianluigi Buffon, as this is the goalkeeper’s 648th Serie A career appearance, allowing him to leave Milan legend Paolo Maldini behind on 647.
Torino’s situation could not be more different to their neighbours, as they are running the genuine risk of relegation after a dire series of results.
They are only four points clear of the drop zone with one win and a draw in their last 10 games.
Daniele Baselli is the only absentee, with Simone Zaza fit for the bench against his former club.
Belotti is the key figure, as always, this time supported by Simone Verdi in a 4-4-2 formation, with Ola Aina and Alex Berenguer on the wings.
Surprisingly, Tomas Rincon is left on the bench.
Toro have only won one of the last 27 Serie A editions of the Derby della Mole, 2-1 in April 2015, along with six draws and 20 defeats.
Juventus: Buffon; Cuadrado, De Ligt, Bonucci, Danilo; Bentancur, Pjanic, Rabiot; Bernardeschi, Dybala, Ronaldo
Juventus bench: Szczesny, Pinsoglio, Rugani, Wesley, Ramsey, Matuidi, Muratore, Douglas Costa, Higuain, Olivieri
Torino: Sirigu; De Silvestri, Izzo, Lyanco, Bremer; Aina, Meite, Lukic, Berenguer; Verdi, Belotti
Torino bench: Ujkani, Rosati, Zaza, Ansaldi, Singo, Edera, Millico, Ghazoini, Djidji, Nkoulou, Adopo, Rincon