Bryan Cristante is set to start as a makeshift centre-back for Roma against Parma, who should recall striker Andreas Cornelius.
The match kicks off at 20:45 UK time – click here for a preview.
With no Chris Smalling, Juan Jesus, Mert Cetin or Davide Santon and Paulo Fonseca having little faith in Federico Fazio, Cristante will drop into defence.
The former Atalanta midfielder will be flanked in Roma’s new-look back three by Gianluca Mancini and Roger Ibanez.
Up top, Carles Perez is expected to get the nod over Justin Kluivert as Edin Dzeko’s strike partner as the Giallorossi look to bounce back from three straight defeats.
As for Parma, Yann Karamoh is likely to make way for Cornelius after the Dane was rested for the 2-1 loss to Sampdoria.
He is set to be flanked by Juventus-bound Dejan Kulusevski and ex-Roma ace Gervinho, who has made just two goalscoring contributions since the restart.
Roma (probable): Lopez; Mancini, Cristante, Ibanez; Spinazzola, Pellegrini, Veretout, Mkhitaryan, Kolarov; Perez, Dzeko
Parma (probable): Sepe; Darmian, Iacoponi, Alves, Gagliolo; Kurtic, Scozzarella, Kucka; Kulusevski, Cornelius, Gervinho
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