Roma are once again forced into changes as they travel to relegation strugglers Brescia, as Nikola Kalinic and Carles Perez start, with Edin Dzeko on the bench.
It kicks off at the Stadio Rigamonti at 18.30 UK time (17.30 GMT).
You can follow all the build-up and action as it happens from this game, Lazio–Sassuolo and Juventus–Atalanta on the LIVEBLOG.
Roma are once again forced into changes as they travel to relegation strugglers Brescia, as Nikola Kalinic and Carles Perez start, with Edin Dzeko on the bench.
It kicks off at the Stadio Rigamonti at 18.30 UK time (17.30 GMT).
The pressure is still on the Giallorossi, who are now in joint fifth place with Napoli and have Milan just behind them.
Their run of three consecutive defeats was ended by a controversial midweek victory over Parma, but problems remain for Paulo Fonseca.
He sticks with the three-man defence, even though Smalling is injured, with Bryan Cristante and Henrikh Mkhitaryan suspended.
Cristante had played at centre-back midweek, but Federico Fazio steps in with Gianluca Mancini and Roger Ibanez.
Edin Dzeko is looking fatigued, so Nikola Kalinic starts with Lorenzo Pellegrini and Carles Perez, dropping Justin Kluivert and Cengiz Under yet again.
Brescia are in penultimate place and seven points adrift of the safety zone, as a brief respite beating Verona was only a blip and they lost 3-1 to Torino on Wednesday.
Andrea Cistana, Dimitri Bisoli and Enrico Alfonso are still on the treatment table, but Jhon Chancellor and Emanuele Ndoj return from injury lay-offs.
Jesse Joronen was in the initial XI, but pulled out with a problem during the warm-up, so Lorenzo Andrenacci steps in.
He is the third choice goalkeeper, but Enrico Alfonso is injured too, so it's Andrenacci's second Serie A game after playing against Juventus.
Brescia: Andrenacci; Sabelli, Chancellor, Papetti, Mangraviti; Ndoj, Tonali, Bjarnason; Spalek; Torregrossa, Skrabb
Roma: Mirante; Mancini, Fazio, Ibanez; Bruno Peres, Veretout, Diawara, Kolarov; Carles Perez, Pellegrini; Kalinic
Ref: Calvarese