Sassuolo are on a run of four consecutive victories and try to take another scalp in Juventus with Jeremie Boga and Domenico Berardi against Gonzalo Higuain and Cristiano Ronaldo.
It kicks off at the Mapei Stadium at 20.45 UK time (19.45 GMT).
If you fancy a punt, then also check out the betting preview for Sassuolo vs. Juventus on Eurotips.co.uk.
Maurizio Sarri’s Juventus moved eight points clear at the top of the table thanks to two handball penalties, which held Atalanta to a 2-2 draw.
They can also thank Sassuolo, who completed a comeback to beat Lazio 2-1 on Saturday with a late Francesco Caputo goal.
That was the Neroverdi’s fourth consecutive victory and they are eager to keep the run going against a Juve side who have been rattled of late.
Berardi, Boga and Filip Djuricic fan out behind hitman Caputo, while Rogerio – who had a very nasty knock to the head during training yesterday that saw him taken to hospital – Gregoire Defrel, Pedro Obiang and Filippo Romagna are out injured.
Juventus miss suspended Juan Cuadrado, so Danilo moves to right-back, bringing Alex Sandro back on the left, but above all Giorgio Chiellini giving Leonardo Bonucci a rest.
Miralem Pjanic also returns, with Federico Bernardeschi, Cristiano Ronaldo and Higuain upfront, resting Paulo Dybala.
Mattia De Sciglio and Sami Khedira are on the treatment table.
Sassuolo: Consigli; Muldur, Chiriches, Peluso, Kyriakopoulos; Magnanelli, Locatelli; Berardi, Djuricic, Boga; Caputo
Juventus: Szczesny; Danilo, De Ligt, Chiellini, Alex Sandro; Bentancur, Pjanic, Matuidi; Bernardeschi, Higuain, Ronaldo
Watch Serie A live in the UK on Premier Sports for just £9.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://www.premiersports.com/subscribenow