Inter are expected to bring back Christian Eriksen but rest Romelu Lukaku against SPAL, who could go with two target men up front.
The match kicks off at 20:45 BST – click here for a preview.
Eriksen was benched for the 3-1 win against Torino, amidst speculation Inter have made him available for transfer this summer.
However, he looks like being given the chance to redeem himself behind Lautaro Martinez and Alexis Sanchez this evening.
The South Americans should stay together in attack, with Antonio Conte unlikely to risk Lukaku for the second game running.
Elsewhere, Ashley Young and Danilo D’Ambrosio should make way for Antonio Candreva and Cristiano Biraghi at wingback.
Inter face Roma three days later - and you can read the betting preview on that match via Eurotips.co.uk here.
SPAL, meanwhile, have lost 10 of their last 12 games and desperately need to turn the tide against Inter.
Luigi Di Biagio has already been warned about his position, so he could pair Andrea Petagna up top with fellow man-mountain Alberto Cerri.
SPAL (probable): Letica; Cionek, Vicari, Tomovic, Reca; D’Alessandro, Valdifiori, Dabo, Strefezza; Petagna, Cerri
Inter (probable): Handanovic; Skriniar, Ranocchia, Bastoni; Candreva, Brozovic, Gagliardini, Biraghi; Eriksen; Lautaro, Alexis
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