Juventus have Juan Cuadrado back, but Cristiano Ronaldo is benched in favour of Alvaro Morata, while Lazio are also forced to reshuffle amid injuries.
It kicks off at 19.45 GMT at the Allianz Stadium in Turin.
You can follow all the build-up and action as it happens from today’s Serie A games on the LIVEBLOG.
Juventus have Juan Cuadrado back, but Cristiano Ronaldo is benched in favour of Alvaro Morata, while Lazio are also forced to reshuffle amid injuries.
It kicks off at 19.45 GMT at the Allianz Stadium in Turin.
You can follow all the build-up and action as it happens from today’s Serie A games on the LIVEBLOG.
This is a head-to-head for the top four, although Lazio have some catching up to do after sliding into seventh place, as the Biancocelesti, Napoli and Juve all have a game in hand.
Both sides have to make changes, as Matthijs de Ligt, Giorgio Chiellini and Paulo Dybala are still injured, with Leonardo Bonucci not at 100 per cent, while Rodrigo Bentancur has COVID-19.
Cuadrado returns to the starting XI after his injury problems, with Federico Chiesa on the other wing, but the big change is upfront, where Ronaldo is not at his best.
Andrea Pirlo opts to rest CR7 in favour of Morata alongside Dejan Kulusevski.
Gianluca Frabotta sits out a ban, leaving Pirlo with limited options, especially ahead of the Champions League decider with Porto, so Under-23 midfielder Nicolò Fagioli had been suggested to start.
Instead, Federico Bernardeschi goes on the right, with Aaron Ramsey and Adrien Rabiot in the centre, resting Weston McKennie.
Lazio continue to miss Luiz Felipe and Stefan Radu, but also lose Manuel Lazzari, forcing some radical changes for Simone Inzaghi.
Adam Marusic is drafted into the three-man defence, moving Senad Lulic to the right wing with Mohamed Fares on the left.
Ciro Immobile leads the attack with Joaquin Correa, Luis Alberto and Sergej Milinkovic-Savic in support.
These sides played a dramatic 1-1 draw in Rome, with Felipe Caicedo coming off the bench to score the last-gasp equaliser.
Lazio haven’t gone unbeaten home and away in a single Serie A season against Juventus since a pair of stalemates in 2005-06.
Juventus: Szczesny; Cuadrado, Demiral, Danilo, Alex Sandro; Bernardeschi, Ramsey, Rabiot, Chiesa; Kulusevski, Morata
Juventus bench: Pinsoglio, Buffon, Arthur, Ronaldo, McKennie, Bonucci, Di Pardo, Dragusin, Fagioli, Peeters, Ake, De Marino
Lazio: Reina; Marusic, Hoedt, Acerbi; Lulic, Milinkovic-Savic, Leiva, Luis Alberto, Fares; Correa, Immobile
Lazio bench: Strakosha, G Pereira, Patric, Pereira, Parolo, Escalante, Caicedo, Cataldi, Musacchio, Shehu, Akpa-Akpro, Muriqi
Ref: Massa