Zlatan Ibrahimovic, Ante Rebic and Hakan Calhanoglu lead the way, as Milan welcome back Theo Hernandez and Ismael Bennacer against Fabio Quagliarella’s Sampdoria.
It kicks off at the Stadio Luigi Ferraris in Genoa at 18.30 UK time (17.30 GMT).
Milan are running out of time to catch Roma in that precious fifth place, which gives direct access to the Europa League group stage, as the gap now stands at four points.
They were able to hold Atalanta to a draw at the weekend, despite being decimated by bans and injuries, but the good news for coach Stefano Pioli is that Theo Hernandez and Bennacer are available again after their suspension.
Alessio Romagnoli, Andrea Conti and Mateo Musacchio are still out of action, so Matteo Gabbia again takes the centre-back role with Simon Kjaer.
Alexis Saelemaekers is chosen rather than fit-again Samu Castillejo to complete the attack with Calhanoglu, Rebic and veteran hitman Ibrahimovic.
Sampdoria had won four out of five games in July, but lost to both Genoa and Scudetto-winners Juventus last week.
Morten Thorsby sits out a ban, with Albin Ekdal on the treatment table, but Gaston Ramirez and Bartosz Bereszynski make a recovery.
Sampdoria: Falcone; Bereszynski, Yoshida, Colley, Augello; Depaoli, Linetty, Vieira, Jankto; Ramirez, Quagliarella
Milan: G Donnarumma; Calabria, Kjaer, Gabbia, Theo Hernandez; Kessie, Bennacer; Saelemaekers, Calhanoglu, Rebic; Ibrahimovic