Atalanta must choose between Ruslan Malinovskyi and Mario Pasalic, while Inter bring back Lautaro Martinez, but consider yet another trequartista instead of Christian Eriksen.
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This is a head-to-head for second place, as whoever wins will get the silver medal behind Juventus, although a draw could potentially let Lazio leapfrog them both.
Atalanta are still without Josip Ilicic and defender Jose Luis Palomino, so Rafael Toloi returns from suspension to complete the defence.
Papu Gomez and Duvan Zapata seem certain to start, with Pasalic and Malinovskyi the challengers for the other slot in attack.
As usual, supersub Luis Muriel is on the bench and ready to shake things up in the second half.
Inter are expected to bring Lautaro Martinez back into the starting XI with Romelu Lukaku, sending Alexis Sanchez to the bench after a series of starts.
The confusion is in the role behind the two strikers, as Eriksen has even more competition, having already been dropped in favour of Borja Valero and Marcelo Brozovic in recent weeks.
There are even more challengers for this position, as Sky Sport Italia point to a more regular 3-5-2 with Roberto Gagliardini back from suspension, while other reports suggest Nicolò Barella could try out as a trequartista.
It remains to be seen whether Marcelo Brozovic will play after another controversial off the field incident, when police were reportedly called to calm him as he insulted medics in an emergency room.
Cristiano Biraghi and Victor Moses could push their way in, replacing Ashley Young and Antonio Candreva.
Atalanta: Gollini; Toloi, Caldara, Djimsiti; Hateboer, De Roon, Freuler, Gosens; Pasalic; Gomez, Duvan Zapata
Inter: Handanovic; Godin, De Vrij, Bastoni; Moses, Brozovic, Gagliardini, Biraghi; Barella; R Lukaku, Lautaro Martinez
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