Nicolò Zaniolo gets his first start since the devastating knee injury suffered during the same game in January, as Roma visit a revamped Juventus.
It kicks off at 19.45 UK time (18.45 GMT).
The Bianconeri have already won the Scudetto and inevitably look ahead to the Champions League Round of 16 clash with Lyon next week, so Cristiano Ronaldo and Matthijs de Ligt aren’t even on the bench.
Paulo Dybala, Douglas Costa, Sami Khedira and Mattia De Sciglio are injured, with Miralem Pjanic suspended.
The team is packed with Under-23 team players, who will be working with new coach Andrea Pirlo next season.
Merih Demiral is on the bench, but expected to make his comeback in the second half.
The Turkey international ruptured his anterior cruciate ligament the last time these sides met, back in January, and has not played since.
Also during that game, Roma starlet Zaniolo was stretchered off with a torn ACL, and this is his first start since that day, although the Italian has made several substitute appearances, scoring a wonderful solo goal against Brescia.
Roma are also rotating their squad ahead of the Europa League decider with Sevilla, having guaranteed fifth place.
Gianluca Mancini is suspended, with Lorenzo Pellegrini, Cengiz Under and Davide Santon unavailable.
Coach Paulo Fonseca is taking the opportunity to give debuts to Brazilian goalkeeper Daniel Fuzato and promising teenage wing-back Riccardo Calafiori.
The Giallorossi are eager to continue their excellent run of six wins and a draw in their last seven rounds, but above all end the eight-year losing streak of their Serie A trips to Turin.
Juventus: Szczesny; Danilo, Rugani, Bonucci, Frabotta; Rabiot, Muratore, Matuidi; Zanimacchia, Higuain, Bernardeschi
Roma: Fuzato; Smalling, Ibanez, Fazio; Zappacosta, Villar, Veretout, Calafiori; Zaniolo, Perotti; Kalinic
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