Atalanta and Inter go head-to-head for second place, with Lazio lying in wait for a draw, with Papu Gomez, Duvan Zapata, Romelu Lukaku and Lautaro Martinez.
It kicks off at the Gewiss Stadium in Bergamo at 19.45 UK time (18.45 GMT).
Inter are currently in second place going into the final round, but just one point clear of both Atalanta and Lazio.
That means whoever wins this match will take the silver medal, while a draw could allow Lazio to leapfrog them both.
La Dea are also just two goals off hitting 100 in a single Serie A season and could set a new all-time club record of eight consecutive league home wins.
Josip Ilicic and Jose Luis Palomino are unavailable, so Rafael Toloi returns from suspension to bolster the defence.
Papu Gomez and Duvan Zapata are untouchable upfront, but Mario Pasalic is preferred to Ruslan Malinovskyi.
Inter miss Stefano Sensi and Matias Vecino, but Antonio Conte once again decides to drop Christian Eriksen.
Instead, it’s either a return to the 3-5-2 formation, or there are reports Nicolò Barella is the surprise experimental choice in the trequartista role behind Romelu Lukaku and Lautaro Martinez.
Atalanta: Gollini; Toloi, Caldara, Djimsiti; Castagne, De Roon, Freuler, Gosens; Pasalic; Gomez, Duvan Zapata
Inter: Handanovic; Godin, De Vrij, Bastoni; D’Ambrosio, Barella, Brozovic, Gagliardini, Young; R Lukaku, Lautaro Martinez
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