Italy make wholesale changes, yet the Netherlands remain more or less intact, as the likes of Ciro Immobile, Nicolò Zaniolo, Manuel Locatelli and Jorginho step in.
The Nations League fixture kicks off in Amsterdam at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
Italy make wholesale changes, yet the Netherlands remain more or less intact, as the likes of Ciro Immobile, Nicolò Zaniolo, Manuel Locatelli and Jorginho step in.
The Nations League fixture kicks off in Amsterdam at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Azzurri saw their 11-match winning streak ended by a 1-1 home draw with Bosnia-Herzegovina on Friday, so this is already an important trip, as Holland top Group A1 thanks to a 1-0 win over Poland.
Roberto Mancini warned he’d make radical changes to the starting XI due to the lack of fitness levels, as Italy are still in pre-season.
Giorgio Chiellini famously was meant to start against Bosnia, but Francesco Acerbi was accidentally used instead after Mancini confessed to checking the line-up sheet without his glasses.
The Juventus veteran does get his first Italy appearance in over a year after all, with Danilo D’Ambrosio and Leonardo Spinazzola stepping in as full-backs.
Nicolò Barella, Gianluigi Donnarumma, Lorenzo Insigne and Leonardo Bonucci are the only players that remain from the XI that started on Friday, as Jorginho, Immobile and Zaniolo return after substitute appearances.
Sassuolo midfielder Locatelli makes his senior Italy debut in midfield, allowing Zaniolo to move into the trident attack with Insigne and European Golden Shoe winner Immobile.
Marco Verratti, Sandro Tonali, Gaetano Castrovilli, Alessio Romagnoli, Federico Bernardeschi and Alessandro Bastoni are among the Italy players unavailable.
The Netherlands are playing under interim coach Dwight Lodeweges, as Ronald Koeman left last month to take the Barcelona job.
Unlike Mancini, he is making very few adjustments from the side that beat Poland 1-0 on Friday.
He’s still missing injured Inter defender Stefan de Vrij and Juventus centre-back Matthijs de Ligt, but Atalanta’s Marten de Roon does start.
Memphis Depay has been linked with Roma and Barcelona, flanked in a trident by Georginio Wijnaldum and Quincy Promes.
Atalanta full-back Hans Hateboer was expected to make way for Denzel Dumfries, who missed Friday’s match because his wife was giving birth.
Instead, he starts and the only change is new Manchester United man Donny van de Beek for Steven Bergwijn, removing the man who scored the winner against Poland.
In the Nations League group games, there is no VAR and only three substitutions are allowed per team.
Netherlands: Cillessen; Hateboer, Veltman, van Dijk, Ake; De Roon, van de Beek, F De Jong; Wijnaldum, Depay, Promes
Netherlands bench: Krul, Bizot, Tete, Fer, Bergwijn, Babel, Schuurs, Strootman, Ihattaren, Wijndal, L De Jong, Dumfries
Italy: G Donnarumma; D'Ambrosio, Bonucci, Chiellini, Spinazzola; Barella, Jorginho, Locatelli; Zaniolo, Immobile, Insigne
Italy bench: Sirigu, Cragno, Di Lorenzo, Cristante, Lo Pellegrini, Belotti, Mancini, Chiesa, Acerbi, Florenzi, Kean, Caputo
Ref: Brych (GER)