Fiorentina begin the season with Giacomo Bonaventura, Franck Ribery, Federico Chiesa and Christian Kouame, while Torino use Alex Berenguer with Andrea Belotti.
It kicks off at 17.00 UK time (16.00 GMT) at the Stadio Franchi and is the opening Serie A game of the 2020-21 season.
The Viola are without new buy Sofyan Amrabat due to suspension, while Erick Pulgar is not yet fully fit after his COVID-19 diagnosis.
Kouame partners Ribery upfront in a 3-5-2 formation, with Chiesa and returning Cristiano Biraghi on the wings, Gaetano Castrovilli embracing his Number 10 jersey.
Toro are under the guidance of a new coach, Marco Giampaolo, but Daniele Baselli, Lyanco and Ricardo Rodriguez are on the treatment table.
Simone Verdi is not 100 per cent fit either, so Alex Berenguer is picked to support Belotti and Simone Zaza.
There’s a start for summer signing Karol Linetty, who already worked with Giampaolo at Sampdoria.
Fiorentina: Dragowski; Milenkovic, Ceccherini, Caceres; Chiesa, Bonaventura, Duncan, Castrovilli, Biraghi; Kouame, Ribery
Torino: Sirigu; Izzo, Nkoulou, Bremer, Ansaldi; Meite, Rincon, Linetty; Berenguer; Zaza, Belotti
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