Inter make changes with Achraf Hakimi, Arturo Vidal, Stefano Sensi and Alexis Sanchez starting against Pippo Inzaghi’s Serie B record-breakers Benevento.
This Serie A Week 1 fixture was postponed from September 19-20 because the Nerazzurri ended last season later due to the Europa League Final.
It kicks off at the Stadio Vigorito at 17.00 UK time (16.00 GMT).
Inter began their campaign with a thrilling 4-3 victory over Fiorentina, having twice gone behind, but have Stefan de Vrij back from suspension to bolster the defence.
Surprisingly, Milan Skriniar gets a rare start in the back three with new buy Aleksandar Kolarov.
New signings Hakimi and Vidal get their first starts, with Ashley Young replacing Ivan Perisic and Stefano Sensi instead of Christian Eriksen.
Alexis Sanchez allows Lautaro Martinez a rest by partnering Romelu Lukaku, while Matias Vecino and Radja Nainggolan are injured.
Benevento also made an impressive comeback in their opening game, from 2-0 down to beat Sampdoria 3-2 in Genoa.
Pippo Inzaghi is again missing Oliver Kragl, Nicolas Viola, Andres Tello, Luca Antei and Massimo Volta, while Iago Falque only arrived yesterday from Torino.
There’s room for 38-year-old Christian Maggio at right-back, formerly of Sampdoria and Napoli, with Gianluca Caprari, Roberto Insigne and Gabriele Moncini in the trident.
Benevento: Montipò; Maggio, Glik, Caldirola, Barba; Ionita, Schiattarella, Dabo; R Insigne, Caprari; Moncini
Inter: Handanovic; Skriniar, De Vrij, Kolarov; Hakimi, Vidal, Gagliardini, Young; Sensi; R Lukaku, Alexis Sanchez