Milan forward Lorenzo Colombo should start against Rio Ave, as coach Stefano Pioli leans on the same XI who overcame Bodo/Glimt in the Europa League.
The match kicks off at 20.00 UK time.
Milan fight Rio Ave for a place in the group stages of the Europa League tonight, a feat worth €15m should the Rossoneri succeed.
And coach Stefano Pioli seems set to give Colombo the responsibility up front in the play-off against the Portuguese side.
Colombo, who scored against Bodo/Glimt last Thursday, should have Hakan Calhanoglu in support again, with Samu Castillejo and Alexis Saelemaekers completing the attacking trident behind the lone striker.
Franck Kessie and Ismael Bennacer will most likely continue in the middle, keeping Sandro Tonali out of the starting line-up.
Ahead of goalkeeper Gianluigi Donnarumma, Simon Kjaer and Matteo Gabbia continue their partnership in the heart of the defence, with Theo Hernandez at left-back and Davide Calabria at right.
Rio Ave, who beat Besiktas on penalties in the last round, are expected to play in the same 4-2-3-1 formation, and former Chievo Verona attacker Lucas Piazon should start on the wing.
The 26-year-old moved on loan from Chelsea last term, having spent 2018-19 at Chievo.
Milan (probable): Donnarumma; Calabria, Kjaer, Gabbia, Theo Hernandez; Kessie, Bennacer; Castillejo, Calhanoglu, Saelemaekers; Colombo
Rio Ave (probable): Kieszek; Ivo Pinto, Borevkovic, Santos, Reis; Tarantini, Felipe Augustino; Piazon, Francisco Geraldes, Carlos Mane; Moreira
Referee: Jesus Gil (ESP)
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