Milan look to youngsters Lorenzo Colombo, Sandro Tonali, Brahim Diaz and Rafael Leao, as they host surprising Spezia.
It kicks off at 17.00 UK time (16.00 GMT). You can follow the build-up and action as it happens from all today’s Serie A games on the LIVEBLOG.
Zlatan Ibrahimovic turned 39 yesterday, but did it in quarantine after testing positive for COVID-19, while natural replacement Ante Rebic is also out with a dislocated elbow.
Teenager Lorenzo Colombo is chosen to lead the attack with Alexis Saelemaekers, Brahim Diaz and Rafael Leao in support.
Tonali gets the nod in midfield rather than Ismael Bennacer, while Alessio Romagnoli, Mateo Musacchio, Andrea Conti and Leo Duarte are long-term absentees.
Spezia are in their first ever Serie A campaign and already got their maiden victory, a 2-0 midweek success away to Udinese, achieved despite Claudio Terzi’s red card.
The captain is therefore suspended, with Jeroen Zoet, Federico Mattiello, Mastinu and Ismajli injured.
Former Milan goalkeeper Rafael therefore takes the gloves, but the danger man is without doubt Andrey Galabinov. Spezia have three Serie A goals in their history and he got all of them.
Milan: G Donnarumma; Calabria, Kjaer, Gabbia, Theo Hernandez; Tonali, Krunic; Saelemaekers, Brahim Diaz, Leao; Colombo
Spezia: Rafael; Sala, Chabot, Erlic, Marchizza; Pobega, Ricci, Maggiore; Verde, Galabinov, Gyasi
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