Aaron Ramsey, Alex Sandro, Cristiano Ronaldo and Weston McKennie are out of the Juventus squad to face Crotone, but Federico Chiesa could debut.
It kicks off at 19.45 UK time (18.45 GMT), click here for a match preview.
Coach Andrea Pirlo released the squad list ahead of this morning’s trip to Calabria, which was delayed until the last minute due to their status in the training ground bubble.
That is because Ronaldo and McKennie both contracted COVID-19.
Also absent are Ramsey, who picked up an injury playing for Wales, Alex Sandro and Matthijs de Ligt.
It leaves precious few options upfront for Pirlo, increasing the chances Paulo Dybala could be given his season debut.
Chiesa could also be given his first appearance in the Bianconeri jersey after his deadline day transfer from Fiorentina.
Juventus squad for Crotone: Szczesny, Pinsoglio, Buffon; Chiellini, Danilo, Cuadrado, Bonucci, Demiral, Frabotta; Arthur, Rabiot, Bentancur, Bernardeschi, Portanova, Rafia, Peeters; Morata, Dybala, Chiesa, Kulusevski, Vrioni
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