Napoli go for broke with the 4-2-3-1 formation, starting Victor Osimhen and Tiemoue Bakayoko, while leaders Atalanta have Josip Ilicic back in the initial XI.
It kicks off at the Stadio San Paolo at 14.00 UK time (13.00 GMT).
The Partenopei are livid after the Disciplinary Commission opted to hand them a 3-0 defeat to Juventus and docked the club a point for not making the journey to Turin.
Although they cited a travel ban by local authorities after Piotr Zielinski and Eljif Elmas tested positive, the Lega Serie A ruled this was a scenario covered by the existing protocol.
Gennaro Gattuso’s men have been self-isolating at a training camp for almost two weeks and that could well have been useful for getting them up to speed on tactics.
The 4-2-3-1 experiment is attempted again, with Dries Mertens, Matteo Politano and Hirving Lozano supporting Osimhen.
Another big change is Bakayoko thrown straight into the starting XI for his debut after the loan move from Chelsea, reuniting with ex-Milan boss Gattuso.
Lorenzo Insigne is still out of action with a muscular problem.
Atalanta have had the perfect start to this season, winning all three matches by scoring four goals, and are gearing up for their second Champions League campaign.
Pierluigi Gollini, Marco Carnesecchi, Mattia Caldara and Cristiano Piccini are on the treatment table, but the big news is the return of Ilicic, who hasn’t played since July 11.
Having taken time to deal with personal issues, the Slovenian was expected to be on the bench, but he is dropped in at the deep end to start with Papu Gomez and Duvan Zapata.
Mario Pasalic plays in midfield, with Fabio Depaoli in for Hans Hateboer.
Napoli: Ospina; Di Lorenzo, Koulibaly, Manolas, Hysaj; Bakayoko, Fabian Ruiz; Politano, Mertens, Lozano; Osimhen
Atalanta: Sportiello; Toloi, Romero, Palomino; Depaoli, De Roon, Pasalic, Gosens; Ilicic, Gomez; Duvan Zapata
Ref: Di Bello
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