It’s a huge Derby della Madonnina, as Romelu Lukaku and Lautaro Martinez face Zlatan Ibrahimovic and Rafael Leao, with Alessio Romagnoli back for Milan and Inter’s defence depleted.
It kicks off at 17.00 UK time (16.00 GMT), follow the build-up and action as it happens on the LIVEBLOG.
This is a battle for the top of the table, as Milan have had a 100 per cent record so far this season, not conceding a single Serie A goal.
Inter are decimated by COVID-19, losing Alessandro Bastoni, Milan Skriniar, Roberto Gagliardini, Ashley Young, Radja Nainggolan and Ionut Radu.
To make matters worse, Stefano Sensi is suspended and Matias Vecino injured, with Alexis Sanchez only fit for the bench after a muscular issue on international duty with Chile.
Nonetheless, Christian Eriksen is still not picked, as Nicolò Barella takes the trequartista role behind Romelu Lukaku and Lautaro Martinez.
Milan shook off their Coronavirus issues, as Ibrahimovic has fully recovered and makes his comeback from the start, supported by Rafael Leao, Alexis Saelemaekers and Hakan Calhanoglu.
Matteo Gabbia, Mateo Musacchio and Andrea Conti are out of action, but captain Romagnoli returns from injury and makes his first appearance of the season.
Inter have won each of the last four Serie A editions of the Derby della Madonnina.
Inter: Handanovic; D’Ambrosio, De Vrij, Kolarov; Hakimi, Vidal, Brozovic, Perisic; Barella; R Lukaku, Lautaro Martinez
Milan: G Donnarumma; Calabria, Kjaer, Romagnoli, Theo Hernandez; Kessie, Bennacer; Saelemaekers, Calhanoglu, Leao; Ibrahimovic
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