Federico Chiesa makes his Juventus debut from the start against Crotone, partnering Alvaro Morata and Dejan Kulusevski, as COVID-19 hits both teams.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action as it happens and give your views on the LIVEBLOG.
The Bianconeri make this trip to Calabria without Cristiano Ronaldo and Weston McKennie, who have COVID-19, plus injured Alex Sandro, Aaron Ramsey and Matthijs de Ligt.
Paulo Dybala is still not at 100 per cent, so coach Andrea Pirlo opts to give Chiesa his debut from the start just days after the deadline day transfer from Fiorentina.
He is joined in the trident by Alvaro Morata and Dejan Kulusevski, while Arthur Melo and Rodrigo Bentancur control the midfield.
Daniele Portanova is a surprise in place of Juan Cuadrado on the right flank.
Giorgio Chiellini and Wojciech Szczesny are rested in favour of Merih Demiral and Gigi Buffon, the goalkeeper making his 650th Serie A appearance.
Crotone have also been struck by COVID-19, as this morning it was announced that Denis Dragus had tested positive after international duty with the Romania Under-21 squad.
Ahmad Benali, Koffi Djidji, Emanuel Riviere and Niccolò Zanellato were also ruled out by injury.
Last season’s Serie B Capocannoniere Simy leads the way, with support from Pedro Pereira, while Arkadiusz Reca and Luca Cigarini provide more attacking threat.
Crotone: Cordaz; Magallan, Marrone, Luperto; Molina, Messias, Cigarini, Vulic, Reca; Pedro Pereira, Simy
Juventus: Buffon; Danilo, Bonucci, Demiral; Portanova, Arthur, Bentancur, Frabotta; Kulusevski; Morata, Chiesa