Edin Dzeko is supported by Henrikh Mkhitaryan and Pedro Rodriguez, as Roma host Pippo Inzaghi’s all-attack Benevento.
It kicks off at 19.45 UK time (18.45 GMT), you can follow the build-up and action as it happens on the LIVEBLOG.
The Giallorossi have stuttered so far this season, getting their first victory thanks to a 1-0 win away to Udinese before the break for international duty.
Chris Smalling finally made the transfer from Manchester United and then immediately picked up an injury, joining Rick Karsdorp, Javier Pastore and Nicolò Zaniolo on the treatment table.
Borja Mayoral is on the bench, but Dzeko again leads the way supported by Pedro and Mkhitaryan.
Davide Santon gets the nod on the right this time, while Bryan Cristante is chosen at centre-back rather than Marash Kumbulla.
Benevento broke Serie B records during their promotion last season and showed no fear against the big clubs in the top flight either, playing out a 5-2 thriller with Inter, beating Sampdoria and Bologna.
Nicolas Viola and Gabriele Moncini are out of action, but there’s an intriguing front three of Iago Falque, Gianluca Caprari and Gianluca Lapadula.
Kamil Glik, Christian Maggio and Artur Ionita also provide plenty of experience, but goalkeeper Lorenzo Montipò has been prone to howlers.
Roma: Mirante; Mancini, Cristante, Ibanez; Santon, Pellegrini, Veretout, Spinazzola; Mkhitaryan, Pedro; Dzeko
Benevento: Montipò; Foulon, Glik, Caldirola, Letizia; Ionita, Schiattarella, Dabo; Iago Falque, Caprari; Lapadula
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