Ciro Immobile, Joaquin Correa and Sergej Milinkovic-Savic lead the way in Lazio’s first Champions League match for 13 years against Erling Haaland and Jadon Sancho’s Borussia Dortmund.
It kicks off at the Stadio Olimpico in Rome at 20.00 UK time (19.00 GMT).
You can follow all the build-up and action as it happens from this game and Dynamo Kiev-Juventus on the LIVEBLOG.
Ciro Immobile, Joaquin Correa and Sergej Milinkovic-Savic lead the way in Lazio’s first Champions League match for 13 years against Erling Haaland and Jadon Sancho’s Borussia Dortmund.
It kicks off at the Stadio Olimpico in Rome at 20.00 UK time (19.00 GMT).
The Biancocelesti are back in Europe’s top tier, but they begin with an incredibly difficult task against young and exciting Bundesliga outfit Borussia Dortmund.
Immobile was suspended for Saturday’s 3-0 Serie A defeat to Sampdoria, so he’ll be fired up against his old club.
Tucu Correa won the battle with Vedat Muriqi to be his strike partner, supported by Luis Alberto and Milinkovic-Savic in midfield.
Manuel Lazzari, Andreas Pereira and Stefan Radu are injured, while Luiz Felipe was a doubt right to the last moment with an ankle problem that has kept him out since September 12.
Adam Marusic therefore returns and Mohamed Fares gets his first start.
Borussia Dortmund are known for their exciting forwards, Erling Braut Haaland and Jadon Sancho, as well as their all-attack style of football.
Former Juventus midfielder Emre Can is suspended, with Nico Schulz, Dan-Axel Zagadou, Marcel Schmelzer and Manuel Akanji out of action.
Defender Lukasz Piszczek had been in doubt with an eye issue, but it’s Marwin Hirtz who is the real surprise, stepping in for Roman Burki.
Lazio: Strakosha; Patric, Luiz Felipe, Acerbi; Marusic, Milinkovic-Savic, Leiva, Luis Alberto, Fares; Correa, Immobile
Lazio bench: Reina, Anderson, Armini, Hoedt, Parolo, Escalante, Caicedo, Czyz, Alia, Akpa-Akpro, Muriqi
Borussia Dortmund: Hitz; Piszczek, Hummels, Delaney; Meunier, Bellingham, Witsel, Guerreiro; Reus, Sancho; Haaland
Borussia Dortmund bench: Burki, Unbehaun, Morey, Dahoud, Brandt, Reinier, Reyna, Passlack, Knauff, Raschl
Ref: Turpin (FRA)