Roma coach Paulo Fonseca could start with Borja Mayoral up front, with Carles Perez and Gonzalo Villar expected in the line-up against Young Boys.
The match kicks off at 17.55 UK time.
The Portuguese coach admitted he will use the match against the Swiss to give some of his fringe players an opportunity to shine, and Pau Lopez should be back in goal for the Giallorossi.
Carles Perez and Villar did well coming off the bench against Benevento and should start in Switzerland, with Borja Mayoral set to replace Edin Dzeko up front.
Marash Kumbulla prepares for his debut in Europe next to Roger Ibanez, as Chris Smalling is not available.
Either Pedro Rodriguez and Henrikh Mkhitaryan completes the attacking trident with Lorenzo Pellegrini behind Borja Mayoral, with Rick Karsdorp and Bruno Peres fight for the place at right-back.
The hosts are tipped to change goalkeeper ahead of the meeting with Roma, as David von Ballmoos could replace Guillaume Faivre between the sticks.
Fabian Lustenberger captains the side from centre-back in a 4-4-2 and Vincent Sierro should start in the middle of the park. Jean Pierre Nsame and Elia Meschack are expected to start up front for the home side.
Young Boys (probable): Von Ballmoos; Hefti, Camara, Lustenberger, Lefort; Fassnacht, Sierro, Aebischer, Ngamaleu; Nsame, Elia
Roma (probable): Pau Lopez; Karsdorp, Ibanez, Kumbulla, Spinazzola; Villar, Cristante; Carles Perez, Pellegrini, Pedro; Borja Mayoral
Referee: Del Cerro (ESP)