Napoli again use Victor Osimhen, Dries Mertens and Hirving Lozano together in a full-strength side against AZ Alkmaar, who are decimated by COVID-19.
The Europa League group phase opener kicks off at the Stadio San Paolo at 17.55 UK time (16.55 GMT).
The Partenopei are fresh from a thrilling 4-1 Serie A victory over Atalanta, which showed just what this new 4-2-3-1 formation can achieve.
It’s repeated here, with Matteo Politano, Mertens and Lozano fanning out behind €80m signing Osimhen.
Piotr Zielinski and Eljif Elmas are still out of action after testing positive for COVID-19, while Lorenzo Insigne is back on the bench following his thigh injury.
There had been some doubts as to whether this match would go ahead at all, because AZ Alkmaar suffered a big Coronavirus outbreak.
Ultimately, they made the trip without nine players, although only one – 19-year-old forward Myron Boadu – was realistically expected to start here.
Among the more familiar faces are Bruno Martins Indi, ex-Sassuolo defender Timo Letschert, captain Teun Koopmeiners and midfielder Jordy Clasie.
There is no VAR in the Europa League group phase.
Napoli: Meret; Di Lorenzo, Maksimovic, Koulibaly, Hysaj; Lobotka, Fabian Ruiz; Politano, Mertens, Lozano; Osimhen
Napoli bench: Contini, Ospina, Demme, Bakayoko, Mario Rui, Insigne, Ghoulam, Rrahmani, Petagna, Manolas
AZ Alkmaar: Bizot; Svensson, Hatzdiakos, Martins Indi, Wijndal; Midtsjo, Stengs, Koopmeiners; Sugawara, De Wit, Karlsson
AZ bench: Verhulst, Evora, Goudmijn, Taabouni, Leeuwin, Gudmundsson, Gullit, Velthuis
Ref: Stefanski (POL)