Borja Mayoral, Pedro, Carles Perez, Gonzalo Villar and Pau Lopez start in a very Spanish-oriented Roma XI away to Young Boys in the Europa League.
It kicks off at the Stadion Wankdorf in Berne at 17.55 UK time (16.55 GMT).
Coach Paulo Fonseca said he would rotate the squad after a 5-2 Serie A victory over Benevento and stayed true to his word, transforming the starting XI.
Chris Smalling is still out injured, while Pedro Rodriguez keeps his spot and Bryan Cristante moves up into midfield.
There’s a very Spanish flavour to the team, including the season debut for goalkeeper Pau Lopez, who has fallen behind Antonio Mirante in the pecking order.
Gonzalo Villar, Carles Perez and ex-Real Madrid striker Borja Mayoral complete the Iberian approach.
Young Boys bring in goalkeeper David Von Ballmoos, while Vincent Sierro starts because he’ll be suspended at the weekend in the league.
Cameroonian striker Jean-Pierre Nsame is partnered by Moumi Ngamaleu rather than Meschack Elia.
Christopher Martins Pereira, Sandro Lauper, Esteban Petignat and Marvin Spielmann are out of action.
Young Boys have a surprisingly good record against Italian teams, winning four of the total six encounters, including all three played on Swiss soil.
Young Boys: Von Ballmoos; Burgy, Lustenberger, Zesiger; Hefti, Rieder, Sierro, Maceiras; Fassnacht, Nsame, Ngamaleu
Young Boys bench: Neuenschwander, Faivre, Camara, Suleijmani, Gaudino, Elia, Siebatcheu, Mambimbi, Aebischer, Maier, Lefort, Seydoux
Roma: Pau Lopez; Kumbulla, Fazio, Juan Jesus; Karsdorp, Villar, Cristante, Peres; Carles Perez, Pedro; Borja Majoral
Roma bench: Boer, Mirante, Ibanez, L Pellegrini, Dzeko, Veretout, Santon, Spinazzola, Mkhitaryan
Ref: Del Cerro Grande (ESP)