Sergej Milinkovic-Savic and Thomas Strakosha are out of the Lazio squad for this evening’s Serie A game against Bologna, so Pepe Reina makes his debut.
It kicks off at 19.45 UK time (18.45 GMT), click here for a match preview.
The Biancocelesti are fresh from a midweek Champions League victory over Borussia Dortmund and it has had an effect on their fitness levels.
Milinkovic-Savic and goalkeeper Strakosha are nursing knocks, so will not even be on the bench this evening.
That means Reina makes his Lazio debut in goal, while Jean-Daniel Akpa Akpro is likely to start after his goal in Europe.
Manuel Lazzari returns to the fold, but Senad Lulic, Danilo Cataldi and Stefan Radu are still out of action.
Lazio squad for Bologna: Alia, Reina; Acerbi, Hoedt, Luiz Felipe, Patric, Vavro, Akpa Akpro, D Anderson, Escalante, Fares, Lazzari, Leiva, Luis Alberto, Marusic, Parolo, Pereira; Caicedo, Correa, Immobile, Muriqi