Lazio make some changes after a thrilling Champions League return, with Pepe Reina making his debut against Rodrigo Palacio’s Bologna.
It kicks off at 19.45 UK time (18.45 GMT) at the Stadio Olimpico.
The Aquile lurched from a 3-0 defeat to Sampdoria straight to a scintillating Champions League victory over Borussia Dortmund on Tuesday evening.
Simone Inzaghi is without Senad Lulic and Stefan Radu, but also rests Sergej Milinkovic-Savic and Thomas Strakosha.
Ciro Immobile and Joaquin Correa are once again the front two, supported by Luis Alberto, with Jean-Daniel Akpa-Akpro promoted to the starting XI after his goal against Dortmund.
There’s a debut in the Lazio jersey for goalkeeper Reina, too, as Strakosha is rested.
Bologna make the trip without Andrea Poli, Gary Medel, Andreas Skov-Olsen and Mitchell Dijks, so the midfield is reshuffled.
Riccardo Orsolini, Roberto Soriano and Nicola Sansone fan out behind veteran striker Rodrigo Palacio, while Aaron Hickey is now a regular at left-back.
Goals are to be expected, seeing as Bologna have conceded in each of their last 37 Serie A games, just one shy of MSV Duisburg’s all-time European record of 38 set in 1975.
Lazio: Reina; Patric, Hoedt, Acerbi; Marusic, Akpa Akpro, Leiva, Luis Alberto, Fares; Correa, Immobile
Bologna: Skorupski; De Silvestri, Tomiyasu, Danilo, Hickey; Schouten, Svanberg; Orsolini, Soriano, Sansone; Palacio