Inter have Achraf Hakimi and Ashley Young back in the Champions League, as Nicolò Barella seems set to play behind the strikers against Shakhtar Donetsk.
The match kicks off at 17.55 UK time.
Hakimi was back in action against Genoa in Serie A, after having missed out against Borussia Mönchengladbach in the first round of the prestigious competition.
Former England international Young is expected to start on the other flank, having overcome coronavirus too.
Marcelo Brozovic and Arturo Vidal seem set to start in the middle of coach Antonio Conte’s 3-4-1-2 in Kiev, as Barella will be pushed up to start in attacking midfield.
Romelu Lukaku and Lautaro Martinez start up front, whilst Danilo D’Ambrosio and Alessandro Bastoni should find place on either side of Stefan de Vrij in the back-three.
Skahktar are not expected to make big changes from the winning side in Madrid ahead of the match with the Nerazzurri.
Castro usually prefers a 4-2-3-1 formation, and should give Dentinho the place up front, with Tete, Marlos and Manor Salomon in the attacking trident behind the centre-forward.
Shakhtar Donetsk (probable): Trubin; Dodo, Khocholava, Bondar, Kornienko; Maycon, Marcos Antonio; Tete, Marlos, Solomon; Dentinho
Inter (probable): Handanovic; D’Ambrosio, De Vrij, Bastoni; Hakimi, Brozovic, Vidal, Young; Barella; Lukaku, Lautaro
Referee: Kabakov (BUL)